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Article

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.

Nature structural & molecular biology - 17 Jun 2012

Schiller Christian B, Lammens Katja, Guerini Ilaria, Coordes Britta, Feldmann Heidi, Schlauderer Florian, Möckel Carolin, Schele Alexandra, Strässer Katja, Jackson Stephen P, Hopfner Karl-Peter

Abstract excerpt

The Mre11-Rad50-Nbs1 (MRN) complex tethers, processes and signals DNA double-strand breaks, promoting genomic stability. To understand the functional architecture of MRN, we determined the crystal structures of the Schizosaccharomyces pombe Mre11 dimeric catalytic domain alone and in complex with...

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Identifiers

PMID: 22705791
DOI: 10.1038/nsmb.2323
PMCID: PMC3392456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22705791-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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