Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.

PloS one - 11 Mar 2011

Kuppers Daniel A, Hwang Harry C, Jackson Aimee L, Linsley Peter S, Clurman Bruce E, Fero Matthew L

Abstract excerpt

Mice lacking the p27(Kip1) Cdk inhibitor (Cdkn1b) exhibit increased susceptibility to lymphomas from the Maloney murine leukemia virus (M-MuLV), and exhibit a high frequency of viral integrations at Xpcl1 (Kis2), a locus on the X-chromosome. Xpcl1 encodes miR-106a~363, a cluster of microRNAs that are expressed in response to adjacent retroviral integrations. We report the first large-scale profile of microRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p27
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Lymphoma

Share to MicroRNAs

Share to Moloney murine leukemia virus

Share to Thymus Gland

Share to Virus Integration

Source

Open in PubMed Open full text

Identifiers

PMID: 21412408
DOI: 10.1371/journal.pone.0014758
PMCID: PMC3055866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.PMID 21412408Read ↗

Identification of oncogenes collaborating with p27 <sup>Kip1</sup> loss by insertional mutagenesis and high-throughput insertion site analysisSemantic proximity Read ↗

c-MYC–miRNA circuitrySemantic proximity Read ↗

Two pathways of p27 <sup>Kip1</sup> degradation are required for murine lymphoma driven by Myc and EBV latent membrane protein 2ASemantic proximity Read ↗

Ago HITS-CLIP Expands Understanding of Kaposi's Sarcoma-associated Herpesvirus miRNA Function in Primary Effusion LymphomasSemantic proximity Read ↗

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors.Semantic proximity Read ↗

MCPIP1 modulates the miRNA‒mRNA landscape in keratinocyte carcinomasSemantic proximity Read ↗

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A.Semantic proximity Read ↗

A Kaposi's Sarcoma-Associated Herpesvirus-Encoded Ortholog of MicroRNA miR-155 Induces Human Splenic B-Cell Expansion in NOD/LtSz-scid IL2Rγ <sup>null</sup> MiceSemantic proximity Read ↗

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.Semantic proximity Read ↗

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Semantic proximity Read ↗

<i>TCL1</i> targeting <i>miR-3676</i> is codeleted with tumor protein p53 in chronic lymphocytic leukemiaSemantic proximity Read ↗

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.