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Article

Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice.

Cancer science - 1 Jun 2007

Kinoshita Anna, Wanibuchi Hideki, Morimura Keiichirou, Wei Min, Nakae Dai, Arai Tsuyoshi, Minowa Osamu, Noda Tetsuo, Nishimura Susumu, Fukushima Shoji

Abstract excerpt

Oxidative stress to DNA is recognized as a mechanism underlying carcinogenic effects of some environmental agents. Here, we hypothesized that dimethylarsinic acid (DMA(V)), an organic metabolite of inorganic arsenic in humans, might exert carcinogenic potential in a mouse line carrying a mutant Mmh allele of the Mmh/OGG1 gene encoding the enzyme 8-hydroxyguanine DNA glycosylase 1 (OGG1). Ogg1 mutant and wild type...

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Source

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Identifiers

PMID: 17441966
DOI: 10.1111/j.1349-7006.2007.00475.x
PMCID: PMC11158468

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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