Article

Construction of a novel 3D urinary bladder mucosa model and its application in toxicity assessment of arsenicals

2025-08-23

Abstract excerpt

The urinary bladder is a major target organ for environmental toxicants, including arsenic. The objects of this study were two-fold. First, we constructed a novel 3D urinary bladder mucosa model that incorporated an overlying epithelium and a supporting subepithelial layer, referred to as the 3D-UBMM. Primary human bladder urothelial and fibroblast cells were immortalized by introducing the human CDK4 R24C and TE...

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Literature Corpus work: ee7d48eb-ec37-562a-badf-4e34724dd80e
DOI: 10.1101/2025.08.19.670771

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