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Article

Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance.

Cell - 12 Jul 2002

Pando Matthew P, Morse David, Cermakian Nicolas, Sassone-Corsi Paolo

Abstract excerpt

The mammalian circadian system contains both central and peripheral oscillators. To understand the communication pathways between them, we have studied the rhythmic behavior of mouse embryo fibroblasts (MEFs) surgically implanted in mice of different genotypes. MEFs from Per1(-/-) mice have a much shorter period in culture than do tissues in the intact animal. When implanted back into mice, however, the Per1(-/-)...

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Identifiers

PMID: 12151001
DOI: 10.1016/s0092-8674(02)00803-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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