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Article

TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.

Blood - 15 Aug 2002

Ho Jenny M-Y, Nguyen Melody H-H, Dierov Jamil K, Badger Karla M, Beattie Bryan K, Tartaro Piero, Haq Rizwan, Zanke Brent W, Carroll Martin P, Barber Dwayne L

Abstract excerpt

The ets transcription factor, TEL, undergoes chromosomal rearrangements with the tyrosine kinase JAK2. TEL-JAK2 is constitutively active, confers cell line factor independence, and activates signal transducer and activator of transcription-1 (STAT1), STAT3, and STAT5. Data from bone marrow transp...

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Source

Identifiers

PMID: 12149229

Genes

JAK2
STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12149229-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.PMID 12149229Read ↗

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