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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

14 Jan 2015

Abstract excerpt

The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a fundamental paradigm for how...

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PMID: 25587654
DOI: 10.1146/annurev-med-051113-024537

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