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Article

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.

Molecular and cellular biology - 1 Sept 2006

Kurzer Jason H, Saharinen Pipsa, Silvennoinen Olli, Carter-Su Christin

Abstract excerpt

The tyrosine kinase Janus kinase 2 (JAK2) transduces signaling for the majority of known cytokine receptor family members and is constitutively activated in some cancers. Here we examine the mechanisms by which the adapter proteins SH2-Bbeta and APS regulate the activity of JAK2. We show that lik...

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Identifiers

PMID: 16914724
DOI: 10.1128/MCB.00570-06
PMCID: PMC1592834

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16914724-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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