Series Introduction: JAK-STAT signaling in human disease

Abstract excerpt

JAK-STAT signaling in human diseaseCytokines, a large family of extracellular ligands, stimulate biological responses in virtually all cell types.One important subfamily of cytokines, the hematopoietins, evolved largely to regulate host responses to exogenous stresses, especially infection with pathogens.They stimulate these responses by binding to and activating a family of structurally and functionally...

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