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Article

Regulation of T cell homeostasis by JAKs and STATs

21 Jul 2007

Abstract excerpt

Regulation of T cell homeostasis is critical for maintaining normal immune function. An imbalance in T cell proliferation can result in disorders ranging from cancer and autoimmunity to immunodeficiencies. Full activation of T cells requires three sequential signals, where signal 3, which is delivered by multiple cytokines, regulates proliferation, differentiation, and survival/death. Signaling from cytokines...

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PMID: 17659375
DOI: 10.1007/s00005-007-0030-x

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