Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.

Brain pathology (Zurich, Switzerland) - 1 Jul 2002

Wirths Oliver, Multhaup Gerd, Czech Christian, Feldmann Nicole, Blanchard Véronique, Tremp Günter, Beyreuther Konrad, Pradier Laurent, Bayer Thomas A

Abstract excerpt

Neuropil deposition of beta-amyloid peptides A beta40 and A beta42 is believed to be the key event in the neurodegenerative processes of Alzheimer's disease (AD). Since A beta seems to carry a transport signal that is required for axonal sorting of its precursor beta-amyloid precursor protein (APP), we studied the intraneuronal staining profile of A beta peptides in a transgenic mouse model expressing human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies

Share to Neurons

Share to Plaque, Amyloid

Share to Presenilin-1

Share to Protein Transport

Share to Surface Plasmon Resonance

Source

Open in PubMed Open full text

Identifiers

PMID: 12146796
DOI: 10.1111/j.1750-3639.2002.tb00442.x
PMCID: PMC8095864

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.PMID 12146796Read ↗

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.Semantic proximity Read ↗

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.Semantic proximity Read ↗

Early intraneuronal Aβ deposition in the hippocampus of APP transgenic miceSemantic proximity Read ↗

Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular AβSemantic proximity Read ↗

Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions.Semantic proximity Read ↗

Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD.Semantic proximity Read ↗

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.Semantic proximity Read ↗

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models.Semantic proximity Read ↗

Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology?Semantic proximity Read ↗

The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.Semantic proximity Read ↗

Presenilins and Alzheimer's disease: the role of A beta 42.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.