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Article

Presenilins and Alzheimer's disease: the role of A beta 42.

Journal of neural transmission. Supplementum - 1 Jan 1998

Eckman C B

Abstract excerpt

The presenilin proteins, localized predominantly to the endoplasmic reticulum, are multi-transmembrane spanning proteins that are processed to form an approximately 27 kD N-terminal fragment and a corresponding 19 kD C-terminal fragment. Mutations in the presenilin 1 and presenilin 2 genes have b...

Topics

Aged
Alzheimer Disease
Amyloid beta-Peptides
Humans
Membrane Proteins
Mutation
Peptide Fragments
Presenilin-1
Presenilin-2

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9700656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9700656-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Presenilins and Alzheimer's disease: the role of A beta 42.PMID 9700656Read ↗

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The role of A beta 42 in Alzheimer's disease.Semantic proximity Read ↗

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.Semantic proximity Read ↗

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[beta-amyloid cascade: current status and future directions].Semantic proximity Read ↗

Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations.Semantic proximity Read ↗

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Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.Semantic proximity Read ↗

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