Presenilins and Alzheimer's disease: the role of A beta 42.

Abstract excerpt

The presenilin proteins, localized predominantly to the endoplasmic reticulum, are multi-transmembrane spanning proteins that are processed to form an approximately 27 kD N-terminal fragment and a corresponding 19 kD C-terminal fragment. Mutations in the presenilin 1 and presenilin 2 genes have been identified that cause early onset familial Alzheimer's disease. Analysis of plasma and fibroblasts from patients...

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