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Article

Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD.

Neurobiology of aging - 1 Oct 2004

Lewis Huw D, Beher Dirk, Smith David, Hewson Louise, Cookson Natalie, Reynolds David S, Dawson Gerard R, Jiang Michael, Van der Ploeg Lex H T, Qian Su, Rosahl Thomas W, Kalaria Raj N, Shearman Mark S

Abstract excerpt

A homogeneous time-resolved fluorescence immunoassay for detection of beta-amyloid (A beta) peptides has been adapted for quantification of A beta(40) and A beta(42) accumulation in brains of APP695SWE transgenic mice. These over-express human beta APP(swe), beta-amyloid precursor protein (beta-APP) containing the K670N/M671L 'Swedish' familial Alzheimer's disease (FAD) mutation. Both peptides start to accumulate...

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PMID: 15312963
DOI: 10.1016/j.neurobiolaging.2003.12.009

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APP

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