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Article

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.

Acta neuropathologica communications - 5 Jun 2014

Iulita M Florencia, Allard Simon, Richter Luise, Munter Lisa-Marie, Ducatenzeiler Adriana, Weise Christoph, Do Carmo Sonia, Klein William L, Multhaup Gerhard, Cuello A Claudio

Abstract excerpt

Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (Aβ) as an important contributor to Alzheimer's disease (AD) pathology, capable of triggering neuroinflammation, tau hyperphosphorylation and cognitive deficits. However, the occurrence and pathological relevance of intracellular Aβ remain a matter of controversial debate. In this study, we have used a multidimensional approach...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24903713
DOI: 10.1186/2051-5960-2-61
PMCID: PMC4229908

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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