Article
TP53 protein expression analysis by luminometric immunoassay in comparison with gene mutation status and prognostic factors in early stage endometrial cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000
Koul Anjila, Bendahl P-O, Borg A, Fernö M, Lidebring M F, Högberg T, Einarsson E L, Ridderheim M, Willén R
Abstract excerpt
Mutations in the TP53 tumor suppressor gene have been shown to significantly correlate with poor prognosis in endometrial cancer. In the present study we have evaluated a luminometric immunoassay (LIA) for quantitative estimation of TP53 protein expression in 65 cytosol preparations from endometrial cancer, previously analyzed for mutations in TP53 exons 4-10. LIA showed high (> or = 0.6 ng/mg protein) expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
