Article
Low molecular weight PTP-IL-4RA interaction in atopy predisposition.
Allergy - 1 Jan 2002
Bottini Nunzio, Mao X-Q, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Shirakawa T, Hopkin J M
Abstract excerpt
We recently described a protective effect of the low molecular weight protein tyrosine phosphatase (LMPTP) BC genotype, associated with the highest total enzymatic activity, against high serum IgE levels both in the English and the Italian populations. Here we test the hypothesis of a role of LMPTP in the negative modulation of IL-4 signal transduction checking for genetic interaction between interleukin-4...
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