Article
Allelic polymorphisms in the interleukin-4 promoter regions and their association with bronchial asthma among the Russian population.
International archives of allergy and immunology - 1 Jan 2006
Gervaziev Y V, Kaznacheev V A, Gervazieva V B
Abstract excerpt
BACKGROUND: Susceptibility to the development of bronchial asthma (BA) and other atopic diseases is known to be associated with genetic components. OBJECTIVE: To evaluate the possible role of the polymorphisms in IL-4 gene promoters (C-33T, C-590T and G-1098T) in modulating allergic response and asthma in the Russian population. METHODS: The polymorphism analysis was carried out by PCR-RFLP; IL-4 and total IgE...
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