Article
Skin testing correlates negatively with high-activity ACP1 *B/*C genotype.
International archives of allergy and immunology - 1 Jan 2008
Greco E, Bottini N, Canu G, Maccari A M, Saccucci P, Gloria-Bottini F, Fontana L
Abstract excerpt
BACKGROUND: Previous studies have shown a negative association between ACP1 *B/*C genotype and total IgE level. ACP1 (acid phosphatase locus 1) is a polymorphic phosphotyrosine phosphatase that interacts with IL4-RA and is involved in T cell receptor signaling. METHODS: In the present paper, we have studied the relationship between *B/*C genotype which shows high ACP1 activity and skin testing in 300 adult...
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