Senescence-like changes induced by expression of p21(waf1/Cip1) in NIH3T3 cell line.

doi:10.1038/sj.cr.7290129

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Article

Senescence-like changes induced by expression of p21(waf1/Cip1) in NIH3T3 cell line.

Cell research - 1 Sept 2002

Chen Xi, Zhang Wei, Gao Yun Fei, Su Xiao Qin, Zhai Zhong He

Abstract excerpt

P21(Waf1/Cip1) is a potent cyclin-dependent kinase inhibitor. As a downstream mediator of p53, p21(Waf1/Cip1) involves in cell cycle arrest, differentiation and apoptosis. Previous studies in human cells provided evidence for a link between p21(Waf1/Cip1) and cellular senescence. While in murine cells, the role of p21(Waf1/Cip1) is indefinite. We explored this issue using NIH3T3 cells with inducible...

Topics

3T3 Cells
Animals
Anti-Bacterial Agents
Cells, Cultured
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Doxycycline
G1 Phase
Gene Expression
Hydrogen-Ion Concentration
Mice
Phenotype
S Phase
Transduction, Genetic
Transformation, Genetic
beta-Galactosidase

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Identifiers

PMID: 12296382
DOI: 10.1038/sj.cr.7290129

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