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Article

Senescence-like changes induced by expression of p21(waf1/Cip1) in NIH3T3 cell line.

Cell research - 1 Sept 2002

Chen Xi, Zhang Wei, Gao Yun Fei, Su Xiao Qin, Zhai Zhong He

Abstract excerpt

P21(Waf1/Cip1) is a potent cyclin-dependent kinase inhibitor. As a downstream mediator of p53, p21(Waf1/Cip1) involves in cell cycle arrest, differentiation and apoptosis. Previous studies in human cells provided evidence for a link between p21(Waf1/Cip1) and cellular senescence. While in murine cells, the role of p21(Waf1/Cip1) is indefinite. We explored this issue using NIH3T3 cells with inducible...

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PMID: 12296382
DOI: 10.1038/sj.cr.7290129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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