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Article

Expression and induction of a large set of drug‐metabolizing enzymes by the highly differentiated human hepatoma cell line BC2

1 Mar 2001

Abstract excerpt

The BC2 cell line derived from the human hepatocarcinoma, HGB, undergoes a spontaneous sharp differentiation process in culture as it becomes confluent, remains stably differentiated for several weeks, and may return to proliferation thereafter under appropriate density conditions. The relevance of the line as an hepatic model has been evaluated. Cells synthesize a large number of plasma proteins, and rates of...

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PMID: 11231298
DOI: 10.1046/j.1432-1327.2001.02011.x

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