Article
Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5.
The International journal of developmental biology - 1 Jan 2002
Stanley Edouard G, Biben Christine, Elefanty Andrew, Barnett Louise, Koentgen Frank, Robb Lorraine, Harvey Richard P
Abstract excerpt
Conditional gene targeting and transgenic strategies utilizing Cre recombinase have been successfully applied to the analysis of development in mouse embryos. To create a conditional system applicable to heart progenitor cells, a Cre recombinase gene linked at its 5' end to an internal ribosome entry site (IRES) was inserted into the 3' untranslated region of the cardiac homeobox gene Nkx2-5 using gene targeting....
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