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Article

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995

Lithgow G J, White T M, Melov S, Johnson T E

Abstract excerpt

We have discovered that three longevity mutants of the nematode Caenorhabditis elegans also exhibit increased intrinsic thermotolerance (Itt) as young adults. Mutation of the age-1 gene causes not only 65% longer life expectancy but also Itt. The Itt phenotype cosegregates with age-1. Long-lived spe-26 and daf-2 mutants also exhibit Itt. We investigated the relationship between increased thermotolerance and...

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Identifiers

PMID: 7638227
DOI: 10.1073/pnas.92.16.7540
PMCID: PMC41375

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