Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

doi:10.1073/pnas.92.16.7540

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Article

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995

Lithgow G J, White T M, Melov S, Johnson T E

Abstract excerpt

We have discovered that three longevity mutants of the nematode Caenorhabditis elegans also exhibit increased intrinsic thermotolerance (Itt) as young adults. Mutation of the age-1 gene causes not only 65% longer life expectancy but also Itt. The Itt phenotype cosegregates with age-1. Long-lived...

Topics

Aging
Alleles
Animals
Caenorhabditis elegans
Female
Genes, Helminth
Hot Temperature
Longevity
Male
Mutation
Stress, Physiological

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