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Article

Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors.

Experimental gerontology - 1 Sept 2000

Johnson T E, Cypser J, de Castro E, de Castro S, Henderson S, Murakami S, Rikke B, Tedesco P, Link C

Abstract excerpt

More than 40 mutants in Caenorhabditis elegans have been demonstrated to lead to increased life span (a rigorous, operational test for being a gerontogene) of 20% or more ("Age" mutants). Age mutants alter rate-limiting determinants of longevity; moreover, important genes are identified independent of prior hypotheses as to actual mode of gene action in extending longevity and/or "slowing" aging. Age mutants...

Topics

Aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Helminth Proteins
Longevity
Mutation
Phosphatidylinositol 3-Kinases
Receptor, Insulin
Stress, Physiological

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PMID: 11053658
DOI: 10.1016/s0531-5565(00)00138-8

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