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Article

Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes.

Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2002

Nishida Akihito, Kubota Takahiro, Yamada Yasuhiko, Higashi Katsumi, Kitamura Kiyoshi, Nakahara Kazuhiko, Iga Tatsuji

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT), which exhibits autosomal codominant polymorphism, plays an important role in the metabolism of thiopurine drugs such as mercaptopurine, thioguanine and azathioprine. Decreased activity of TPMT is associated with severe hematopoietic toxicity after administration of standard doses of these drugs. METHODS: We developed a specific high-performance liquid...

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Source

Identifiers

PMID: 12135816
DOI: 10.1016/s0009-8981(02)00184-5

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thiopurine S-methyltransferase activity in Japanese subjects: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes.PMID 12135816Read ↗

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