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Article

Thiopurine S-methyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate.

European journal of clinical pharmacology - 1 May 1998

Kröplin T, Weyer N, Gutsche S, Iven H

Abstract excerpt

OBJECTIVES: To develop a non-radioactive assay to measure thiopurine S-methyltransferase (TPMT) activity. The assay was used to study the distribution of TPMT activity in a healthy German population. METHODS: The assay is based on the conversion of 6-thioguanine (6-TG) to 6-methylthioguanine (6-MTG) using non-radiolabelled S-adenosyl-L-methionine (SAM) as the methyl donor. At the end of the incubation period (60...

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PMID: 9681671
DOI: 10.1007/s002280050457

Genes

TPMT

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Thiopurine S-methyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate.PMID 9681671Read ↗

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