Article
Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium.
Mechanisms of development - 1 Aug 2002
Coates Juliet C, Grimson Mark J, Williams Robin S B, Bergman Wayland, Blanton Richard L, Harwood Adrian J
Abstract excerpt
Aardvark (Aar) is a Dictyostelium beta-catenin homologue with both cytoskeletal and signal transduction roles during development. Here, we show that loss of aar causes a novel phenotype where multiple stalks appear during late development. Ectopic stalks are preceded by misexpression of the stalk marker ST-lacZ in the surrounding tissue. This process does not involve the kinase GSK-3. Mixing experiments show that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.