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Article

Characterization of the Roco protein family in Dictyostelium discoideum.

Eukaryotic cell - 1 May 2010

van Egmond Wouter N, van Haastert Peter J M

Abstract excerpt

The Roco family consists of multidomain Ras-GTPases that include LRRK2, a protein mutated in familial Parkinson's disease. The genome of the cellular slime mold Dictyostelium discoideum encodes 11 Roco proteins. To study the functions of these proteins, we systematically knocked out the roco genes. Previously described functions for GbpC, Pats1, and QkgA (Roco1 to Roco3) were confirmed, while novel developmental...

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Identifiers

PMID: 20348387
DOI: 10.1128/EC.00366-09
PMCID: PMC2863948

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