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Article

Role of cis prolines 112 and 126 in the functional activity of ribonucleolytic toxin restrictocin.

Biochemical and biophysical research communications - 26 Jul 2002

Goyal Anita, Seth Divya, Batra Janendra K

Abstract excerpt

Restrictocin is a 149 amino acid ribonucleolytic toxin produced by the fungus Aspergillus, which specifically cleaves a single phosphodiester bond within 28S rRNA resulting in a potent inhibition of protein synthesis in eukaryotic cells. Restrictocin has 12 prolines out of which three at positions 48, 112, and 126 are cis. Prolines at position 112, 118, and 126 were individually mutated to alanine to investigate...

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Identifiers

PMID: 12127966
DOI: 10.1016/s0006-291x(02)00780-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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