Article
The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner.
PloS one - 1 Jan 2013
Bojsen Rasmus, Torbensen Rasmus, Larsen Camilla Eggert, Folkesson Anders, Regenberg Birgitte
Abstract excerpt
The peptidomimetic LTX109 (arginine-tertbutyl tryptophan-arginine-phenylethan) was previously shown to have antibacterial properties. Here, we investigated the activity of this novel antimicrobial peptidomimetic on the yeast Saccharomyces cerevisiae. We found that LTX109 was an efficient fungicide that killed all viable cells in an exponentially growing population as well as a large proportion of cells in biofilm...
Topics
- Amino Acids
- Amphotericin B
- Biofilms
- Biological Transport
- Cell Membrane
- Drug Resistance, Fungal
- Fluorescent Dyes
- Fungicides, Industrial
- Gene Deletion
- Microbial Viability
- Mutation
- Oligopeptides
- Potassium
- Protons