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Article

Cysteine 116 participates in intermolecular bonding of the human VEGF(121) homodimer.

Archives of biochemistry and biophysics - 1 Aug 2002

Gaspar Nicholas J, Jue Rodney A, Hu Jie, Puchacz Elzbieta, deForest Nikol L, Schellenberger Ute

Abstract excerpt

VEGF(121), the 121-amino acid form of vascular endothelial growth factor is a homodimer with nine cysteine residues per monomer. While three intramolecular and two intermolecular disulfide bonds have been mapped, the state of the ninth cysteine, Cys116, is not known. In this study, we determined that human VEGF(121) contains a third interchain disulfide bond between Cys116 of each monomer. We also isolated a...

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Identifiers

PMID: 12127077
DOI: 10.1016/s0003-9861(02)00239-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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