Article
VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells.
The Journal of biological chemistry - 12 May 1995
Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi B Z, Neufeld G
Abstract excerpt
Four vascular endothelial growth factor (VEGF) splice variants containing 121, 165, 189, and 206 amino acids are produced from a single human gene as a result of alternative splicing. VEGF121 is not a heparin-binding protein, while the other VEGF species possess heparin binding ability. YU-ZAZ6 human melanoma cells expressed the mRNA encoding the VEGF receptor flt-1, but not the mRNA encoding the VEGF receptor...
Topics
- Alternative Splicing
- Binding Sites
- Cell Division
- Cell Line
- Cell Membrane
- Cross-Linking Reagents
- Endothelial Growth Factors
- Gene Expression
- Genetic Variation
- Heparin