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Article

The von Willebrand factor predicted unpaired cysteines are essential for secretion.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2014

Shapiro S E, Nowak A A, Wooding C, Birdsey G, Laffan M A, McKinnon T A J

Abstract excerpt

BACKGROUND: von Willebrand factor (VWF) contains free thiols that mass spectroscopy has located to nine cysteines: two in the D3 domain (Cys889 and Cys898) and seven in the C domains (Cys2448, Cys2451, Cys2453, Cys2490, Cys2491, Cys2528, and Cys2533) (J Biol Chem, 7, 2007, 35604; Blood, 118, 5312). It has been suggested that these free thiols function to regulate the self-association of VWF through...

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PMID: 24283831
DOI: 10.1111/jth.12466

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VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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