Article
Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells.
The Journal of biological chemistry - 8 Mar 1996
Gitay-Goren H, Cohen T, Tessler S, Soker S, Gengrinovitch S, Rockwell P, Klagsbrun M, Levi B Z, Neufeld G
Abstract excerpt
VEGF121 and VEGF165 are vascular endothelial growth factor splice variants that promote the proliferation of endothelial cells and angiogenesis. VEGF165 contains the 44 additional amino acids encoded by exon 7 of the VEGF gene. These amino acids confer upon VEGF165 a heparin binding capability which VEGF121 lacks. 125I-VEGF165 bound to three vascular endothelial growth factor (VEGF) receptors on endothelial...
Topics
- Animals
- Binding, Competitive
- Cell Line
- Cells, Cultured
- Chloramines
- Electrophoresis, Polyacrylamide Gel
- Endothelial Growth Factors
- Endothelium, Vascular
- Genetic Variation
- Heparin