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Article

Assignment of intrachain disulfide bonds in platelet-derived growth factor B-chain.

The Journal of biological chemistry - 25 Jun 1993

Ostman A, Andersson M, Bäckström G, Heldin C H

Abstract excerpt

Platelet-derived growth factor (PDGF)-BB is a dimeric protein held together by two disulfide bonds involving the 2nd and 4th cysteine residues from the NH2 terminus. To localize the three intrachain disulfide bonds in PDGF, a method was devised that made it possible to cleave PDGF at specific sit...

Topics

Animals
Cell Line
Cyanogen Bromide
Cysteine
Disulfides
Electrophoresis, Polyacrylamide Gel
Humans
Mutation
Platelet-Derived Growth Factor
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-sis
Receptors, Platelet-Derived Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8514775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8514775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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