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Article

Assignment of intrachain disulfide bonds in platelet-derived growth factor B-chain.

The Journal of biological chemistry - 25 Jun 1993

Ostman A, Andersson M, Bäckström G, Heldin C H

Abstract excerpt

Platelet-derived growth factor (PDGF)-BB is a dimeric protein held together by two disulfide bonds involving the 2nd and 4th cysteine residues from the NH2 terminus. To localize the three intrachain disulfide bonds in PDGF, a method was devised that made it possible to cleave PDGF at specific sites. A set of PDGF derivatives in which specific amino acids were mutated to methionine residues was generated. The...

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PMID: 8514775

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SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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