VEGF-A121a binding to Neuropilins - A concept revisited.

Abstract excerpt

All known splice isoforms of vascular endothelial growth factor A (VEGF-A) can bind to the receptor tyrosine kinases VEGFR-1 and VEGFR-2. We focus here on VEGF-A121a and VEGF-A165a, two of the most abundant VEGF-A splice isoforms in human tissue 1 , and their ability to bind the Neuropilin co-receptors NRP1 and NRP2. The Neuropilins are key vascular, immune, and nervous system receptors on endothelial cells,...

Topics

• Animals
• Endothelium, Vascular
• Humans
• Mutation
• Neuropilins
• Receptor Protein-Tyrosine Kinases
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor Receptor-2