Article
Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations.
The Journal of biological chemistry - 30 Dec 1994
Pötgens A J, Lubsen N H, van Altena M C, Vermeulen R, Bakker A, Schoenmakers J G, Ruiter D J, de Waal R M
Abstract excerpt
Vascular permeability factor, or vascular endothelial growth factor (VPF/VEGF) is an important factor in the regulation of vascular growth and vascular permeability. VPF is a secreted, dimeric protein and has 8 cysteine residues conserved with platelet-derived growth factor (PDGF). To study the role of some of these cysteine residues in maintaining the structure and function of VPF, we replaced the codons for the...
Topics
- Binding, Competitive
- Biopolymers
- Cysteine
- Endothelial Growth Factors
- Lymphokines
- Mutation
- Serine
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors