Article
No evidence of association between the alpha-2 macroglobulin gene and Parkinson's disease in a case-control sample.
Neuroscience letters - 2 Aug 2002
Nicoletti Giuseppe, Annesi Grazia, Tomaino Carmine, Spadafora Patrizia, Pasqua Angela Aurora, Annesi Ferdinanda, Serra Paolo, Caracciolo Manuela, Messina Demetrio, Zappia Mario, Quattrone Aldo
Abstract excerpt
Alpha-2 macroglobulin (A2M) is a component of Lewy bodies, a hallmark of Parkinson's disease (PD). In 159 PD patients and 190 normal controls, we studied two A2M polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism method: a five-nucleotide deletion at the 5' splice site of exon 18; and a valine to isoleucine exchange in amino acid position 1000 near the thiolester active site....
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