Article
Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.
Neuroreport - 3 Aug 2000
Krüger R, Menezes-Saecker A M, Schöls L, Kuhn W, Müller T, Woitalla D, Berg D, Berger K, Przuntek H, Epplen J T, Riess O
Abstract excerpt
Recent association studies investigating polymorphisms in the alpha2-macroglobulin (A2M) gene provided evidence for an involvement of this protease inhibitor in the pathogenesis of Alzheimer's disease (AD). The partially overlapping pathology between AD and Parkinson's disease (PD) led us to investigate the role of A2M in PD. We performed association studies in a large sample of 328 German PD patients and 322...
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