Article
Genetic polymorphisms of superoxide dismutase in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2001
Farin F M, Hitosis Y, Hallagan S E, Kushleika J, Woods J S, Janssen P S, Smith-Weller T, Franklin G M, Swanson P D, Checkoway H
Abstract excerpt
Oxidative stress reactions may contribute to the pathogenesis of Parkinson's disease (PD). The superoxide dismutases potentially play significant roles in PD by detoxifying superoxide radical. We developed genomic DNA and cDNA-based sequencing assays to identify genetic variants in the copper/zinc superoxide dismutase (SOD1) and manganese superoxide dismutase (SOD2) genes. No genetic variants were detected in the...
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