Article
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.
Neuron - 3 Jul 2002
Meng Yanghong, Zhang Yu, Tregoubov Vitali, Janus Christopher, Cruz Luis, Jackson Mike, Lu Wei Yang, MacDonald John F, Wang Jay Y, Falls Douglas L, Jia Zhengping
Abstract excerpt
In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams syndrome, a mental disorder with profound deficits in visuospatial cognition. However, the in vivo function of this family of kinases remains elusive. Using LIMK-1 knockout mice, we demonstrate a significant role for...
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