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Article

Roles of LIM kinases in central nervous system function and dysfunction

3 Nov 2015

Abstract excerpt

LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the...

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Identifiers

PMID: 26545494
DOI: 10.1016/j.febslet.2015.10.032

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