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Article

Extrusion of penem antibiotics by multicomponent efflux systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Aug 2002

Okamoto Kiyomi, Gotoh Naomasa, Nishino Takeshi

Abstract excerpt

The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC beta-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpC- and MexAB-OprM-deficient background and found that MexAB-OprM is the most important among the...

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Identifiers

PMID: 12121960
DOI: 10.1128/AAC.46.8.2696-2699.2002
PMCID: PMC127373

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Source receipt: pubmed, retrieved 7 Sept 2026.

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