Article
Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems.
Antimicrobial agents and chemotherapy - 1 Feb 1999
Köhler T, Michea-Hamzehpour M, Epp S F, Pechere J C
Abstract excerpt
While meropenem MICs were strongly influenced by the presence or absence of the MexAB-OprM efflux pump in both OprD-proficient and -deficient strain backgrounds, MICs of imipenem and of ER-35786 remained unchanged, demonstrating that meropenem is a substrate of MexAB-OprM but not imipenem and ER-...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Anti-Bacterial Agents
- Biological Transport
- Carbapenems
- Drug Resistance, Microbial
- Microbial Sensitivity Tests
- Mutation
- Porins
- Pseudomonas aeruginosa