Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.

doi:10.1128/AAC.44.12.3322-3327.2000

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Article

Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Dec 2000

Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T

Abstract excerpt

To find the exact substrate specificities of three species of tripartite efflux systems of Pseudomonas aeruginosa, MexAB-OprM, MexCD-OprJ, and MexXY-OprM, we constructed a series of isogenic mutants, each of which constitutively overproduced one of the three efflux systems and lacked the other two, and their isogenic mutants, which lacked all these systems. Comparison of the susceptibilities of the constructed...

Topics

Bacterial Outer Membrane Proteins
Bacterial Proteins
Biological Transport, Active
Carrier Proteins
Lactams
Membrane Proteins
Membrane Transport Proteins
Mutation
Pseudomonas aeruginosa
Substrate Specificity

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Identifiers

PMID: 11083635
DOI: 10.1128/AAC.44.12.3322-3327.2000
PMCID: PMC90200

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