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Article

The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa.

Biochemical and biophysical research communications - 28 Apr 1997

Yoneyama H, Ocaktan A, Tsuda M, Nakae T

Abstract excerpt

The antibiotic extrusion machinery in Pseudomonas aeruginosa is assembled from the mex-operon encoded proteins, OprM and MexA-MexB, connecting the outer and inner membranes. To envisage the role of these proteins in antibiotic extrusion and resistance, we employed the gene replacement technique to construct mutants deficient in mexA, mexB, or oprM, and all possible combinations of these genes. Using the Southern...

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Identifiers

PMID: 9168899
DOI: 10.1006/bbrc.1997.6506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa.PMID 9168899Read ↗

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Construction of a series of mutants lacking all of the four major mex operons for multidrug efflux pumps or possessing each one of the operons from Pseudomonas aeruginosa PAO1: MexCD-OprJ is an inducible pump.Semantic proximity Read ↗

Contribution of the MexAB-OprM multidrug efflux system to the beta-lactam resistance of penicillin-binding protein and beta-lactamase-derepressed mutants of Pseudomonas aeruginosa.Semantic proximity Read ↗

Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosaSemantic proximity Read ↗

Linkage of the efflux-pump expression level with substrate extrusion rate in the MexAB-OprM efflux pump of Pseudomonas aeruginosa.Semantic proximity Read ↗

Functional cloning and characterization of a multidrug efflux pump, mexHI-opmD, from a Pseudomonas aeruginosa mutant.Semantic proximity Read ↗

A novel assembly process of the multicomponent xenobiotic efflux pump in Pseudomonas aeruginosa.Semantic proximity Read ↗

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Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump.Semantic proximity Read ↗

The Role of Multidrug Efflux Pumps in the Antibiotic Resistance of <i>Pseudomonas aeruginosa</i> and Other Gram‐Negative BacteriaSemantic proximity Read ↗

Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.Semantic proximity Read ↗

MexXY Multidrug Efflux System Is More Frequently Overexpressed in Ciprofloxacin Resistant French Clinical Isolates Compared to Hospital Environment OnesSemantic proximity Read ↗

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