Article
The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa.
Biochemical and biophysical research communications - 28 Apr 1997
Yoneyama H, Ocaktan A, Tsuda M, Nakae T
Abstract excerpt
The antibiotic extrusion machinery in Pseudomonas aeruginosa is assembled from the mex-operon encoded proteins, OprM and MexA-MexB, connecting the outer and inner membranes. To envisage the role of these proteins in antibiotic extrusion and resistance, we employed the gene replacement technique t...
Topics
- 4-Quinolones
- Anti-Bacterial Agents
- Anti-Infective Agents
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Biological Transport, Active
- Chromosomes, Bacterial
- Drug Resistance, Microbial
- Gene Deletion
- Genes, Bacterial
- Membrane Proteins
- Models, Biological
- Mutation
- Protein Conformation
- Pseudomonas aeruginosa