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Article

Antibiotic efflux mechanisms

1 Dec 1999

Abstract excerpt

Bacterial genomes sequenced to date almost invariably contain genes apparently coding for multidrug efflux pumps, and the yeast genome contains more than 30 putative multidrug efflux genes. Thus it is not surprising that multidrug efflux is a major cause of intrinsic drug resistance in many microorganisms, and plays an even more prominent role in organisms with a low-permeability cell wall, such as Gram negative...

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PMID: 17035817
DOI: 10.1097/00001432-199912000-00001

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