Article
Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic.
Scientific reports - 16 Jan 2017
Chalhoub Hussein, Pletzer Daniel, Weingart Helge, Braun Yvonne, Tunney Michael M, Elborn J Stuart, Rodriguez-Villalobos Hector, Plésiat Patrick, Kahl Barbara C, Denis Olivier, Winterhalter Mathias, Tulkens Paul M, Van Bambeke Françoise
Abstract excerpt
The β-lactam antibiotic temocillin (6-α-methoxy-ticarcillin) shows stability to most extended spectrum β-lactamases, but is considered inactive against Pseudomonas aeruginosa. Mutations in the MexAB-OprM efflux system, naturally occurring in cystic fibrosis (CF) isolates, have been previously shown to reverse this intrinsic resistance. In the present study, we measured temocillin activity in a large collection...
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