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Article

Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Feb 1999

Masuda N, Gotoh N, Ishii C, Sakagawa E, Ohya S, Nishino T

Abstract excerpt

We investigated the role of chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa. Determination of the susceptibilities of a series of isogenic mutants with impaired production of the beta-lactamase and the efflux system to 16 beta-lactams including penicillins, cephems, oxacephems, carbapenems, and a monobactam demonstrated that the...

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Identifiers

PMID: 9925544
DOI: 10.1128/AAC.43.2.400
PMCID: PMC89089

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Source receipt: pubmed, retrieved 7 Sept 2026.

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