Article
Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.
Molecular microbiology - 1 Mar 1997
Wang P, Read M, Sims P F, Hyde J E
Abstract excerpt
Sulfadoxine/pyrimethamine (Fansidar) is widely used in Africa for treating chloroquine-resistant falciparum malaria. To clarify how parasite resistance to this combination arises, various lines of Plasmodium falciparum were used to investigate the role of naturally occurring mutations in the targ...
Topics
- Alleles
- Animals
- Antimalarials
- Dihydropteroate Synthase
- Drug Antagonism
- Drug Combinations
- Drug Resistance, Microbial
- Folic Acid
- Genetic Linkage
- Humans
- Malaria, Falciparum
- Microbial Sensitivity Tests
- Plasmodium falciparum
- Polymerase Chain Reaction
- Pyrimethamine
- Recombination, Genetic
- Sequence Analysis, DNA
- Sulfadoxine