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Article

Mutations in cytochrome b resulting in atovaquone resistance are associated with loss of fitness in Plasmodium falciparum.

Antimicrobial agents and chemotherapy - 1 Aug 2002

Peters Jennifer M, Chen Nanhua, Gatton Michelle, Korsinczky Michael, Fowler Elizabeth V, Manzetti Sergio, Saul Allan, Cheng Qin

Abstract excerpt

Drug resistance in malarial parasites has become a major obstacle in the control of the disease. Strategies are urgently needed to control the development of resistance and to possibly reverse existing resistance. One key element required to reverse malaria drug resistance is for the parasites to "pay" a biological "cost" or suffer a loss of fitness when acquiring resistance to antimalarial drugs. Such a...

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Identifiers

PMID: 12121915
DOI: 10.1128/AAC.46.8.2435-2441.2002
PMCID: PMC127342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in cytochrome b resulting in atovaquone resistance are associated with loss of fitness in Plasmodium falciparum.PMID 12121915Read ↗

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Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo(2)) of the cytochrome b gene.Semantic proximity Read ↗

The impact of antimalarial drug resistance mutations on parasite fitness, and its implications for the evolution of resistance.Semantic proximity Read ↗

Cytochrome b Drug Resistance Mutation Decreases Babesia Fitness in the Tick Stages But Not the Mammalian Erythrocytic Cycle.Semantic proximity Read ↗

Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene.Semantic proximity Read ↗

Impaired fitness of drug-resistant malaria parasites: evidence and implication on drug-deployment policies.Semantic proximity Read ↗

Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance.Semantic proximity Read ↗

The interplay between drug resistance and fitness in malaria parasitesSemantic proximity Read ↗

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